Frusciante is known to use mostly vintage guitars, including:
*Two 1940s Martin acoustics
*1950s Gibson ES-335 Two Color Sunburst
*1955 Gretsch White Falcon
*1957 Fender Stratocaster Two Color Sunburst, maple fretboard
*1960s Gibson SG Sunburst
*1961 Fender Stratocaster Two Color Sunburst, rosewood fretboard
*1961 Gibson SG Custom Cherry Red
*1961 Fender Stratocaster, Olympic White, rosewood fretboard
*1962 Fender Stratocaster, Three Color Sunburst, rosewood fretboard
*1962 Fender Jaguar Fiesta Red
*1963 Fender Custom Telecaster, rosewood fretboard
*1965 Fender Custom Telecaster, rosewood fretboard
*1965 Fender Duo-Sonic Olympic White, rosewood fretboard
*1969 Fender Mustang Fiesta Red (Practice Guitar)
*1969 Gibson Les Paul Black Beauty
*Ibanez RG 250 DX (used during Mother's Milk)
*Maton Messiah 12-string acoustic (which can be heard on "Breaking the Girl")
*Mosrite St.George Gold 12-string electric
*Fender Precision Bass Olympic White, rosewood fretboard
His 1955 Stratocaster was used in the recording of Blood Sugar Sex Magik, and the 1962 Stratocaster was given to him as a present by bandmate Anthony Kiedis (due to John having sold all of his guitars during a particularly low drugs period) after he returned to the band. He has also been seen playing a Gibson Les Paul Black Beauty guitar, mainly during the Red Hot Chili Peppers tour in 2004 for the cover song, "Black Cross", he also can be seen playing a Gibson SG Custom in the music video for "Fortune Faded".
John has been seen playing a Toronado in the video for "Can't Stop", although on a commentary audio track for the music video included on the DVD that accompanied the 2003 RHCP Greatest Hits album, John states that he only used the guitar for the video because the director asked him to.
As of 2006, John has been seen playing a number of different guitars in the Red Hot Chili Peppers' music video for "Dani California", involving the band paying tribute to several bands including The Beatles and Nirvana. Towards the end of the video, the band "become" themselves and John plays a white 1961 Fender Stratocaster, with its visible wear and tear. It is similar to a white Stratocaster Jimi Hendrix used, who is one of John's major influences.
John uses his beat up red Mustang to warm up before a concert. One of his original Jaguars was stolen back in the early '90s, though it is not certain if the blue or green one was stolen. John also has a white Fender Precision Bass, which is seen in the "Past Recedes" video. Most likely, it is a vintage pre-'65 P-Bass. Also visible in the video is a miniature acoustic.
*Fender Blackface Showman
*Fender Twin Reverb (John keeps this next to his pedalboard)
*Marshall 100W Super Bass
*Marshall Silver Jubilee 100
*Marshall 200W Major
He primarily uses Marshall amplifiers, mainly two Silver Jubilee and a 200-watt Major. Although, has also been seen using amps by Vox and Fender.
John has used and/or is still using the following effects.
*BOSS OD-1 Overdrive (used early in his career with the RHCP, but quickly removed from his pedal board)
*BOSS DS-1 Distortion (used solely in the Mother's Milk era, and for the song "Otherside")
*BOSS DS-2 Distortion
*Electro-Harmonix USA Big Muff Pi Distortion/Sustainer
*Electro Harmonix - English Muff'n
*Electro-Harmonix Graphic Fuzz
*Z.Vex Fuzz Factory
*BOSS CE-1 Chorus Ensemble (Also used for Vibrato effects greatly used on "Stadium Arcadium").
*Electro-Harmonix Electric Mistress Flanger & Filter Matrix
*Electro-Harmonix Frequency Analyzer
*Electro-Harmonix Micro Synthesizer
*Electro-Harmonix Tube Zipper
*Electro-Harmonix POG (Polyphonic Octave Generator)
*Line 6 FM4 Filter Modeler
*Moog MF-103 MoogerFooger 12 Stage Phaser
*MXR Phase 90 (re-issue)
*Dunlop Univibe Stereo Chorus
*Jim Dunlop Crybaby Wah-Wah
*Ibanez WH-10 Wah-Wah (John's preferred Wah today. John has several of these pedals, as they are long discontinued, and due to being made of plastic, break easily.)
*BOSS Master Switch
*BOSS FV-50 Volume pedal
*MXR Micro Amp (John uses this to get more output from the pickups in his Strats)
Frusciante's pedalboard for the Californication tour was rather modest, only five pedals, though his effects arsenal for the By the Way tour was considerably larger. John used a wide variety of modular synth gear in the studio for the making of Stadium Arcadium.
Guitar Strings / Picks
Frusciante uses D'Addario EXL110 strings (0.10 - 0.46) with a .11 for the thin "E", and orange Dunlop Tortex .60mm plectrums